ABSTRACT
Introduction: COVID-19 disease is currently pandemic, and its prevalence in Saudi Arabia is concerning. The SARS-CoV-2 virus primarily affects the lungs, but it also affects the haematopoietic system. The atypical lymphocytes on peripheral blood film that have a distinct morphological appearance were of particular interest in this study. Our goal was to see a link between atypical lymphocytes and COVID-19 patient mortality. Methods: This four-month single-centered prospective descriptive study was conducted in Makkah, Saudi Arabia. COVID-19 patients of both genders were randomly selected based on inclusion criteria. The data from the patient's electronic medical record was extracted. All patients' peripheral blood film parameters were recorded on days 3, 7, and 14 after admission. The statistical data was analysed using SPSS version 23. The Fisher's exact test was used to determine the relationship with mortality. A p value of 0.05 was considered significant. Results: The total number of cases enrolled in the study was 226. The patients' average age was 58 years (SD 0.5289). On the third day of admission, 88.2 % of patients with COVID-19 had atypical lymphocytes, with a mean of 2.35 ± 0.927. A significant correlation (p < 0.001) exists between atypical lymphocytes decreasing percentage number on the 3rd, 7th, and 14th days of admission and death. Conclusion: The decrease in the number of atypical lymphocytes on peripheral blood film has a significant association with the patients' mortality. This fact can be used to develop a tailored management strategy based on the observation of peripheral blood film. © 2022 UPM Press. All rights reserved.
ABSTRACT
Rationale: Human myiasis is the invasion of tissue or organs by fly larvae. This could be obligatory, facultative, or accidental. Patient concerns: A 4-year-old Saudi boy complained of fever over the past three days with multiple inflamed painful dermal furuncles and worms-like discharge. Diagnosis: Furuncular obligatory myiasis caused by Wohlfahrtia magnifica. Interventions: Maggots were removed for identification. The wounds were cleaned with antiseptic dressings. Topical and oral antibiotics were applied. Outcomes: Seven days later, the wounds completely healed. Lessons: Although several reports correlated human myiasis with old age, low health status, mental retardation, and low socioeconomic status, but the patient in our case was a healthy child from a family with good socioeconomic status, good hygiene, no history of diseases or mental disability, but traveled to a village where the climate is suitable for fly breeding.
ABSTRACT
The local dynamics with different topological classifications, bifurcation analysis and chaos control in a discrete-time COVID-19 epidemic model are investigated in the interior of $ \mathbb{R}_+^3 $. It is proved that discrete-time COVID-19 epidemic model has boundary equilibrium solution for all involved parameters, but it has an interior equilibrium solution under definite parametric condition. Then by linear stability theory, local dynamics with different topological classifications are investigated about boundary and interior equilibrium solutions of the discrete-time COVID-19 epidemic model. Further for the discrete-time COVID-19 epidemic model, existence of periodic points and convergence rate are also investigated. It is also investigated the existence of possible bifurcations about boundary and interior equilibrium solutions, and proved that there exists no flip bifurcation about boundary equilibrium solution. Moreover, it is proved that about interior equilibrium solution there exists hopf and flip bifurcations, and we have studied these bifurcations by utilizing explicit criterion. Next by feedback control strategy, chaos in the discrete COVID-19 epidemic model is also explored. Finally numerically verified theoretical results.